Neue virustatische Produkte                        

Nucleoside analogs

• 3TC (Glaxo Wellcome Inc, FDA approved around '95)
  • - Synergistic with zidovudine
  • - sustained antiviral effect
  • - Combo is new "first-line" therapy for AIDS
• didanosine, VidexR, ddI
• zalcitabine (ddC)
• stavudine, ZeritR, d4T

Protease inhibitors [Neergaard, J&C; 3/96]

• Long term usefulness still not known
• saquinavir (Hoffman LaRoche, FDA approved 12/95)
• ritonavir (Abbott Labs., FDA approved 3/96)
• indinavir (Merck & Co, FDA approved 3/96)
• nelfinavir (Agouron Inc, FDA approval expected '97)

Combinations -- exciting current development [Neergaard, J&C;3/96]

Use of these with nucleoside analogs decreases blood HIV by up to 98%

In 3/96 recommended therapy to postpone AIDS includes--

• zidovudine
• 3TC
• ritonavir

Other combinations being tested, some 4 drug mixtures

Drugs in testing stage

• nevaripine
• delvaripine